THE SIXTH ANNUAL MEETING OF THE ISRAELI SOCIETY FOR CANCER RESEARCH (ISCR)
FROM MECHANISMS TO THERAPIES
Haifa, 22 May, 2014
SCIENTIFIC PROGRAM
08:00 Gathering and Registration, Poster Viewing and Visit the Exhibition 09:10 OPENING REMARKS
Yuval Shaked, Chairman of the organizing committee
Dept. of Molecular Pharmacology, Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
Eliezer Shalev, Dean of Ruth & Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technolog, Haifa, Israel
Yona Keisari, President of the Israeli Society for Cancer Research
09:30 – 11:00 Session 1 Ruth Auditorium
GENETIC AND EPIGENETIC MECHANISMS IN TUMORIGENESIS
Chair: Sol Efroni, Israel
Amir M. Orian
Rappaport Research Institute and Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
09:50 NEW INSIGHTS INTO THE EFFECT OF CANCER GENES ON DNA REPLICATION AND GENOME STABILITY
Batsheva Kerem
Dept. of Genetics, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
10:10 CANCER AND RNA EPIGENETICS
Gidi Rechavi
Dept. of Genetics and Biochemistry and Cancer Research Center, The Chaim Sheba Medical Center, Tel Hashomer, Israel
10:30 Keynote Lecture
REGULATION AND ROLES OF THE P53 PROTEIN IN CANCER
Carol Prives
Dept. of Biological Sciences at Columbia University, New York, NY, USA 11:00 Coffee Break, Poster Viewing and Visit the Exhibition
11:20 – 12:45 Parallel Session 2A Ruth Auditorium
NEW APPROACHES IN CANCER DETECTION, IMAGING AND TREATMENT
Chair: Alberto Gabizon, Israel
11:20 REALIZING THE PROMISE OF CANCER IMMUNOTHERAPY
Hyam Levitsky
Global Head Cancer Immunology Experimental Medicine Hoffmann La Roche, Pharma Research and Early Development, Schlieren, Switzerland
Sponsored by Roche Pharmaceuticals (Israel) Ltd.
11:50 WHOLE-EXOME SEQUENCING IDENTIFIES RECURRENT FUNCTIONAL MUTATIONS IN MELANOMA
Yardena Samuels
Dept. of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
12:10 MODELING TREATMENT OF ADVANCED METASTATIC DISEASE IN MICE AS A PREDICTIVE CLINICAL BIOMARKER
Robert S. Kerbel
Dept. of Medical Biophysics, Sunnybrook Research Institute, Toronto, Canada
12:30 **DELAYED CONTRAST MRI – A NOVEL TOOL FOR DECISION MAKING IN NEURO-ONCOLOGY
Yael Mardor
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; Advanced Technology Center, Sheba Medical Center, Ramat Gan, Israel
11:20 – 12:40 Parallel Session 2B Red Auditorium
ADVANCES IN HEMATOLOGICAL MALIGNANCIES
Chair: Benjamin Brenner, Israel
11:20 ANTILEUKEMIC POTENTIAL OF COMBINATIONS OF NATURAL AGENTS WITH DISTINCT MECHANISMS OF ACTION
Michael Danilenko
Dept. of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Beer Sheva, Israel
11:40 STEM CELL TRANSPLANTATION AND TARGETED THERAPIES IN HEMATOLOGICAL MALIGNANCIES
Arnon Nagler
Hematology Division, BMT and CBB, Chaim Sheba Medical Center, Tel Hashomer, Israel
**Selected Abstract for Presentation
11:20 – 12:40 Parallel Session 2B (cont.) Red Auditorium
Yishai Ofran
Dept. of Hematology and Bone Marrow Transplantation, Technion/Rambam, Haifa, Israel
12:20 **MIR-30E TARGETS BCR-ABL1 AND SENSITIZES K562 CELLS TO IMATINIB TREATMENT
Oshrat Hershkovitz Rokah
Felsenstein Medical Research Center, Beilinson Hospital; Sackler School of Medicine, Tel Aviv University, Petah Tikva, Israel
12:40 – 13:00 ISCR BUSINESS SESSION Ruth Auditorium
13:00 Light Lunch Break, Poster Viewing and Visit the Exhibition
14:00 – 15:30 Session 3 Ruth Auditorium
METABOLIC PATHWAYS IN CANCER
Chair: Amir M. Orian, Israel
14:00 Keynote Lecture
*MTOR SIGNALING IN GROWTH AND METABOLISM
Michael N. Hall
Biozentrum, University of Basel, Basel, Switzerland
14:30 KLOTHO: FROM AGING SUPPRESSION TO REGULATION OF TUMOR METABOLISM
Ido Wolf
The Oncology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
14:50 THE ROLE OF SIRT6 IN METABOLISM AND CANCER
Haim Cohen
Molecular Mechanism of Aging Lab, Bar Ilan University, Ramat Gan, Israel
15:10 ELUCIDATING THE ROLE OF LIPOPROTEINS IN TUMOR-RELATED ANGIOGENESIS AND METASTASIS
Karina Yaniv
Dept. of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
15:30 Coffee Break, Poster Viewing and Visit the Exhibition
*In Memory of Prof. Eliezer Flescher
**Selected Abstract for Presentation
15:50 – 17:15 Parallel Session 4A Ruth Auditorium
THE TUMOR MICROENVIRONMENT AND THE IMMUNE SYSTEM
Chair: Angel Porgador, Israel
15:50 IMMUNE CHECKPOINT INHIBITORS FOR CANCER IMMUNOTHERAPY
Gal Markel
Ella Institute of Melanoma, Sheba Medical Center, Ramat Gan;
Dept. of Clinical Microbiology & Immunology, Sackler Faculty of Medicine, Tel Aviv University, Israel
Sponsored by BMS Israel
16:20 **THE ROLE OF LONG NON-CODING RNA (MALAT1) IN TUMOR INITIATION AND METASTASIS
Pushkar Malakar
Dept. of Biochemistry and Molecular Biology, Institute for Medical Research Israel Canada (IMRIC), Hebrew University Hadassah Medical School, Jerusalem, Israel
16:35 THE ROLE OF CCR5 IN DIRECTING THE ACCUMULATION OF MYELOID DERIVED SUPPRESSOR CELLS AT THE TUMOR SITE
Nathan Karin
Dept. of Immunology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Adit Ben-Baruch
Dept. Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel
15:50 – 17:05 Parallel Session 4B Red Auditorium
CANCER SIGNALING
Chair: Ami Aronheim, Israel
Ella Evron
Dept. of Oncology, Assaf Harofeh Medical Center, Zerifin, Israel
16:05 SENESCENCE AND THERAPY INDUCED SENESCENCE – ROLE OF PKC
Etta Livneh
The Shraga Segal Dept. of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Beer Sheva, Israel
**Selected Abstract for Presentation
15:50 – 17:05 Parallel Session 4B (cont.) Red Auditorium
16:25 FROM TARGETED TO MULTI-TARGETED CANCER TREATMENTS
Alexander Levitzki
Unit of Cellular Signaling, Dept. of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem Jerusalem, Israel
Izhak Haviv
Medicine, Bar Ilan University, Zefat, Israel
17:15 CONCLUDING REMARKS Ruth Auditorium
Poster Awards